|Other Names||E3 ubiquitin-protein ligase MARCH5, 632-, Membrane-associated RING finger protein 5, Membrane-associated RING-CH protein V, MARCH-V, Mitochondrial ubiquitin ligase, MITOL, RING finger protein 153, MARCH5, RNF153|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.|
|Cellular Location||Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors (PubMed:16874301) show its presence only in mitochondria (PubMed:16874301).|
|Tissue Location||Expressed in brain, heart, liver, lung, spleen, stomach, testis, skeletal and muscle|
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Provided below are standard protocols that you may find useful for product applications.
MARCH5 is a ubiquitin ligase of the mitochondrial outermembrane that plays a role in the control of mitochondrialmorphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1(DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed16936636]).
Yonashiro, R., et al. Mol. Biol. Cell 20(21):4524-4530(2009)Karbowski, M., et al. J. Cell Biol. 178(1):71-84(2007)Nakamura, N., et al. EMBO Rep. 7(10):1019-1022(2006)
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