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CASQ1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P31415 |
|---|---|
| Other Accession | NP_001222.2 |
| Clone Names | 90723025 |
| Gene ID | 844 |
|---|---|
| Other Names | Calsequestrin-1, Calmitine, Calsequestrin, skeletal muscle isoform, CASQ1, CASQ |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CASQ1 |
|---|---|
| Synonyms | CASQ |
| Function | Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle (PubMed:28895244). Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions (PubMed:28895244). Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity (PubMed:27185316). |
| Cellular Location | Endoplasmic reticulum Sarcoplasmic reticulum. Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P07221}. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side {ECO:0000250|UniProtKB:P07221}. Mitochondrion matrix {ECO:0000250|UniProtKB:O09165}. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Preferentially forms linear and round aggregates in the endoplasmic reticulum (ER) of resting cells (PubMed:28895244). In a minority of cells, homogeneously detected in the ER lumen (PubMed:28895244). Colocalizes with STIM1 at endoplasmic reticulum in response to a depletion of intracellular calcium (PubMed:27185316). {ECO:0000250|UniProtKB:P07221, ECO:0000269|PubMed:27185316, ECO:0000269|PubMed:28895244} |
| Tissue Location | Expressed in myoblasts (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
CASQ1 is a mitochondrialcalcium-binding protein located in the luminal space of theterminal cisternae of the sarcoplasmic reticulum. The protein bindsand putatively stores calcium ions. The protein is absent inpatients with Duchenne and Becker types of muscular dystrophy.
References
Wilton, S.B., et al. Heart Rhythm 5(5):694-700(2008)Hasstedt, S.J., et al. Ann. Hum. Genet. 72 (PT 2), 163-169 (2008) Sparso, T., et al. Mol. Genet. Metab. 92(3):278-282(2007)
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