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CALCR Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P30988 |
|---|---|
| Other Accession | NP_001733.1 |
| Clone Names | 90723155 |
| Gene ID | 799 |
|---|---|
| Other Names | Calcitonin receptor, CT-R, CALCR |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CALCR (HGNC:1440) |
|---|---|
| Function | This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CALCR is a high affinity receptor for the peptidehormone calcitonin and belongs to a subfamily of seventransmembrane-spanning G protein-coupled receptors. The encodedprotein is involved in maintaining calcium homeostasis and inregulating osteoclast-mediated bone resorption. Polymorphisms inthis gene have been associated with variations in bone mineraldensity and onset of osteoporosis.
References
Nussenzveig, D.R., et al. Endocrinology 136(5):2047-2051(1995)Nakamura, M., et al. Biochem. Biophys. Res. Commun. 209(2):744-751(1995)Egerton, M., et al. J. Mol. Endocrinol. 14(2):179-189(1995)Gorn, A.H., et al. J. Clin. Invest. 90(5):1726-1735(1992)
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