|Other Names||Calcitonin receptor, CT-R, CALCR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
CALCR is a high affinity receptor for the peptidehormone calcitonin and belongs to a subfamily of seventransmembrane-spanning G protein-coupled receptors. The encodedprotein is involved in maintaining calcium homeostasis and inregulating osteoclast-mediated bone resorption. Polymorphisms inthis gene have been associated with variations in bone mineraldensity and onset of osteoporosis.
Nussenzveig, D.R., et al. Endocrinology 136(5):2047-2051(1995)Nakamura, M., et al. Biochem. Biophys. Res. Commun. 209(2):744-751(1995)Egerton, M., et al. J. Mol. Endocrinol. 14(2):179-189(1995)Gorn, A.H., et al. J. Clin. Invest. 90(5):1726-1735(1992)
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