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ZC3HAV1 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q7Z2W4
Other Accession NP_064504.2
Clone Names 91102130
Peptide ID 91102130
Additional Information
Gene ID 56829
Other Names Zinc finger CCCH-type antiviral protein 1, ADP-ribosyltransferase diphtheria toxin-like 13, ARTD13, Zinc finger CCCH domain-containing protein 2, Zinc finger antiviral protein, ZAP, ZC3HAV1, ZC3HDC2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZC3HAV1
Synonyms ZC3HDC2
Function Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)- specific ribonuclease PARN to remove the poly(A) tail, and the 3'- 5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).
Cellular Location Isoform 1: Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner
Research Areas
Citations (0)

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ZC3HAV1 is a CCCH-type zinc finger protein that isthought to prevent infection by retroviruses. Studies of the rathomolog indicate that the protein may primarily function to inhibitviral gene expression and induce an innate immunity to viralinfection.


Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Bick, M.J., et al. J. Virol. 77(21):11555-11562(2003)Katoh, M., et al. Int. J. Oncol. 23(2):541-547(2003)Gao, G., et al. Science 297(5587):1703-1706(2002)

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$ 80.00
Cat# BP5695b
(40 western blots)
Availability: In Stock
Bulk Size
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