|Other Names||Putative RNA-binding protein 15, One-twenty two protein 1, RNA-binding motif protein 15, RBM15, OTT, OTT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation.|
|Cellular Location||Nucleus. Nucleus membrane; Peripheral membrane protein. Nucleus speckle Nucleus, nucleoplasm Note=Colocalizes at the nuclear pore with DBP5 and NXF1|
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Provided below are standard protocols that you may find useful for product applications.
Members of the SPEN (Split-end) family of proteins,including RBM15, have repressor function in several signalingpathways and may bind to RNA through interaction with spliceosomecomponents (Hiriart et al., 2005 [PubMed 16129689]).[supplied byOMIM].
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Ma, Z., et al. Nat. Genet. 28(3):220-221(2001)Mercher, T., et al. Proc. Natl. Acad. Sci. U.S.A. 98(10):5776-5779(2001)
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