|Other Names||MyoD family inhibitor, Myogenic repressor I-mf, MDFI|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity).|
|Cellular Location||Nucleus. Cytoplasm|
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This protein is a transcription factor that negativelyregulates other myogenic family proteins. Studies of the mousehomolog, I-mf, show that it interferes with myogenic factorfunction by masking nuclear localization signals and preventing DNAbinding. Knockout mouse studies show defects in the formation ofvertebrae and ribs that also involve cartilage formation in thesestructures.
Snider, L., et al. Mol. Cell. Biol. 21(5):1866-1873(2001)Kraut, N., et al. EMBO J. 17(21):6276-6288(1998)Kraut, N. Mamm. Genome 8(8):618-619(1997)Chen, C.M., et al. Cell 86(5):731-741(1996)
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