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MDFI Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q99750
Other Accession NP_005577.1
Clone Names 91102137
Peptide ID 91102137
Additional Information
Gene ID 4188
Other Names MyoD family inhibitor, Myogenic repressor I-mf, MDFI
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity).
Cellular Location Nucleus. Cytoplasm
Research Areas
Citations (0)

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This protein is a transcription factor that negativelyregulates other myogenic family proteins. Studies of the mousehomolog, I-mf, show that it interferes with myogenic factorfunction by masking nuclear localization signals and preventing DNAbinding. Knockout mouse studies show defects in the formation ofvertebrae and ribs that also involve cartilage formation in thesestructures.


Snider, L., et al. Mol. Cell. Biol. 21(5):1866-1873(2001)Kraut, N., et al. EMBO J. 17(21):6276-6288(1998)Kraut, N. Mamm. Genome 8(8):618-619(1997)Chen, C.M., et al. Cell 86(5):731-741(1996)

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$ 80.00
Cat# BP5698c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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