|Other Names||Sperm-associated antigen 1, HSD-38, Infertility-related sperm protein Spag-1, SPAG1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity.|
|Cellular Location||Cytoplasm. Note=Colocalizes with tubulin|
|Tissue Location||Present in most tissues, including lung, with the strongest expression in brain, colon, kidney, and testis. In sperm and testis, detected in particular in pachytene primary spermatocytes. Up-regulated in pancreatic tumor tissues and not in normal pancreatic tissue.|
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The correlation of anti-sperm antibodies with cases ofunexplained infertility implicates a role for these antibodies inblocking fertilization. Improved diagnosis and treatment ofimmunologic infertility, as well as identification of proteins fortargeted contraception, are dependent on the identification andcharacterization of relevant sperm antigens. The protein expressedby this gene is recognized by anti-sperm agglutinating antibodiesfrom an infertile woman. Furthermore, immunization of female ratswith the recombinant human protein reduced fertility. This proteinlocalizes to the plasma membrane of germ cells in the testis and tothe post-acrosomal plasma membrane of mature spermatozoa.Recombinant polypeptide binds GTP and exhibits GTPase activity.Thus, this protein may regulate GTP signal transduction pathwaysinvolved in spermatogenesis and fertilization. Two transcriptvariants of this gene encode the same protein. [provided byRefSeq].
Lin, W., et al. Mol. Hum. Reprod. 7(9):811-818(2001)Diekman, A.B., et al. Am. J. Reprod. Immunol. 37(1):111-117(1997)Zhang, M.L., et al. Chin. Med. J. 105(12):998-1003(1992)
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