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SPAG1 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q07617
Other Accession NP_003105.2
Clone Names 91102138
Peptide ID 91102138
Additional Information
Gene ID 6674
Other Names Sperm-associated antigen 1, HSD-38, Infertility-related sperm protein Spag-1, SPAG1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPAG1
Function May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity.
Cellular Location Cytoplasm. Note=Colocalizes with tubulin
Tissue Location Present in most tissues, including lung, with the strongest expression in brain, colon, kidney, and testis. In sperm and testis, detected in particular in pachytene primary spermatocytes. Up-regulated in pancreatic tumor tissues and not in normal pancreatic tissue.
Research Areas
Citations (0)

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The correlation of anti-sperm antibodies with cases ofunexplained infertility implicates a role for these antibodies inblocking fertilization. Improved diagnosis and treatment ofimmunologic infertility, as well as identification of proteins fortargeted contraception, are dependent on the identification andcharacterization of relevant sperm antigens. The protein expressedby this gene is recognized by anti-sperm agglutinating antibodiesfrom an infertile woman. Furthermore, immunization of female ratswith the recombinant human protein reduced fertility. This proteinlocalizes to the plasma membrane of germ cells in the testis and tothe post-acrosomal plasma membrane of mature spermatozoa.Recombinant polypeptide binds GTP and exhibits GTPase activity.Thus, this protein may regulate GTP signal transduction pathwaysinvolved in spermatogenesis and fertilization. Two transcriptvariants of this gene encode the same protein. [provided byRefSeq].


Lin, W., et al. Mol. Hum. Reprod. 7(9):811-818(2001)Diekman, A.B., et al. Am. J. Reprod. Immunol. 37(1):111-117(1997)Zhang, M.L., et al. Chin. Med. J. 105(12):998-1003(1992)

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$ 80.00
Cat# BP5699a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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