|Other Names||Regulator of G-protein signaling 9-binding protein, RGS9-anchoring protein, RGS9BP, R9AP|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation (By similarity).|
|Cellular Location||Membrane; Single-pass type IV membrane protein|
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RGS9BP functions as a regulatorof G protein-coupled receptor signaling in phototransduction.Studies in bovine and mouse show that this gene is expressed onlyin the retina, and is localized in the rod outer segment membranes.This protein is associated with a heterotetrameric complex,specifically interacting with the regulator of G-protein signaling9, and appears to function as the membrane anchor for the otherlargely soluble interacting partners. Mutations in this gene areassociated with prolonged electroretinal response suppression(PERRS), also known as bradyopsia.
Cheng, J.Y., et al. Arch. Ophthalmol. 125(8):1138-1140(2007)Nishiguchi, K.M., et al. Nature 427(6969):75-78(2004)Hu, G., et al. J. Biol. Chem. 278(16):14550-14554(2003)Hu, G., et al. Proc. Natl. Acad. Sci. U.S.A. 99(15):9755-9760(2002)
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