|Other Names||Voltage-dependent calcium channel subunit alpha-2/delta-4, Voltage-gated calcium channel subunit alpha-2/delta-4, Voltage-dependent calcium channel subunit alpha-2-4, Voltage-dependent calcium channel subunit delta-4, CACNA2D4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Predominantly expressed in certain types of endocrine cells. Present in the Paneth cells of the small intestine. Also present in the erythroblasts in the fetal liver, in the cells of the zona reticularis of the adrenal gland and in the basophils of the pituitary. Present at low level in some brain regions such as the cerebellum (at protein level)|
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CACNA2D4 is a member of the alpha-2/delta subunitfamily, a protein in the voltage-dependent calcium channel complex.Calcium channels mediate the influx of calcium ions into the cellupon membrane polarization and consist of a complex of alpha-1,alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Variousversions of each of these subunits exist, either expressed fromsimilar genes or the result of alternative splicing. Research on ahighly similar protein in rabbit suggests the protein described inthis record is cleaved into alpha-2 and delta subunits. Alternatetranscriptional splice variants of this gene have been observed buthave not been thoroughly characterized.
Wycisk, K.A., et al. Am. J. Hum. Genet. 79(5):973-977(2006)Qin, N., et al. Mol. Pharmacol. 62(3):485-496(2002)
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