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MPP8 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q99549
Other Accession NP_059990.2
Clone Names 91113012
Peptide ID 91113012
Additional Information
Gene ID 54737
Other Names M-phase phosphoprotein 8, Two hybrid-associated protein 3 with RanBPM, Twa3, MPHOSPH8, MPP8
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MPHOSPH8 (HGNC:29810)
Synonyms MPP8
Function Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592).
Cellular Location Nucleus. Chromosome Note=Detected on heterochromatin (PubMed:20871592, PubMed:26022416). Dissociates from chromatin during interphase and early mitosis (PubMed:23416073). Detected on nucleosomes (PubMed:20871592).
Research Areas
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References

Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Maksimov, V.V., et al. Genetika 42(2):274-277(2006)Dunham, A., et al. Nature 428(6982):522-528(2004)

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$ 80.00
Cat# BP5718a
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