|Other Names||Very low-density lipoprotein receptor, VLDL receptor, VLDL-R, VLDLR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein|
|Tissue Location||Abundant in heart and skeletal muscle; also ovary and kidney; not in liver|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The low density lipoprotein receptor (LDLR) gene familyconsists of cell surface proteins involved in receptor-mediatedendocytosis of specific ligands. This gene encodes a lipoproteinreceptor that is a member of the LDLR family and plays importantroles in VLDL-triglyceride metabolism and the reelin signalingpathway. Mutations in this gene cause VLDLR-associated cerebellarhypoplasia. Alternative splicing generates multiple transcriptvariants encoding distinct isoforms for this gene. [provided byRefSeq].
Sakai, K., et al. Brain Res. 1276, 11-21 (2009)Francis, P.J., et al. J. Med. Genet. 46(5):300-307(2009)Ananyeva, N.M., et al. Blood Coagul. Fibrinolysis 19(6):543-555(2008)Turkmen, S., et al. Eur. J. Hum. Genet. 16(9):1070-1074(2008)
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