|Other Names||Very low-density lipoprotein receptor, VLDL receptor, VLDL-R, VLDLR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein|
|Tissue Location||Abundant in heart and skeletal muscle; also ovary and kidney; not in liver|
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Provided below are standard protocols that you may find useful for product applications.
The low density lipoprotein receptor (LDLR) gene familyconsists of cell surface proteins involved in receptor-mediatedendocytosis of specific ligands. This gene encodes a lipoproteinreceptor that is a member of the LDLR family and plays importantroles in VLDL-triglyceride metabolism and the reelin signalingpathway. Mutations in this gene cause VLDLR-associated cerebellarhypoplasia. Alternative splicing generates multiple transcriptvariants encoding distinct isoforms for this gene. [provided byRefSeq].
Sakai, K., et al. Brain Res. 1276, 11-21 (2009)Francis, P.J., et al. J. Med. Genet. 46(5):300-307(2009)Ananyeva, N.M., et al. Blood Coagul. Fibrinolysis 19(6):543-555(2008)Turkmen, S., et al. Eur. J. Hum. Genet. 16(9):1070-1074(2008)
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