VLDLR Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P98155 |
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Other Accession | NP_003374.3 |
Clone Names | 90625263 |
Gene ID | 7436 |
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Other Names | Very low-density lipoprotein receptor, VLDL receptor, VLDL-R, VLDLR |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | VLDLR |
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Function | Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE- containing ligands as well as clusterin/CLU (PubMed:24381170, PubMed:30873003). In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8 (PubMed:30873003). Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (PubMed:30873003). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity). |
Cellular Location | Cell membrane; Single-pass type I membrane protein Membrane, clathrin-coated pit; Single-pass type I membrane protein |
Tissue Location | Abundant in heart and skeletal muscle; also ovary and kidney; not in liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
The low density lipoprotein receptor (LDLR) gene familyconsists of cell surface proteins involved in receptor-mediatedendocytosis of specific ligands. This gene encodes a lipoproteinreceptor that is a member of the LDLR family and plays importantroles in VLDL-triglyceride metabolism and the reelin signalingpathway. Mutations in this gene cause VLDLR-associated cerebellarhypoplasia. Alternative splicing generates multiple transcriptvariants encoding distinct isoforms for this gene. [provided byRefSeq].
References
Sakai, K., et al. Brain Res. 1276, 11-21 (2009)Francis, P.J., et al. J. Med. Genet. 46(5):300-307(2009)Ananyeva, N.M., et al. Blood Coagul. Fibrinolysis 19(6):543-555(2008)Turkmen, S., et al. Eur. J. Hum. Genet. 16(9):1070-1074(2008)
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