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PLA2G4C Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UP65 |
|---|---|
| Other Accession | NP_003697.1 |
| Clone Names | 90625179 |
| Gene ID | 8605 |
|---|---|
| Other Names | Cytosolic phospholipase A2 gamma, cPLA2-gamma, Phospholipase A2 group IVC, PLA2G4C |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PLA2G4C |
|---|---|
| Function | Calcium-independent phospholipase, lysophospholipase and O- acyltransferase involved in phospholipid remodeling with implications in endoplasmic reticulum membrane homeostasis and lipid droplet biogenesis (PubMed:19501189, PubMed:9705332, PubMed:10085124, PubMed:10358058, PubMed:28336330). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:19501189, PubMed:9705332, PubMed:10085124, PubMed:10358058, PubMed:28336330). Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at sn-1 position of lysophospholipids (PubMed:19501189, PubMed:15944408). Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency (PubMed:19501189, PubMed:15944408). In response to dietary fatty acids, may play a role in the formation of nascent lipid droplets from the endoplasmic reticulum likely by regulating the phospholipid composition of these organelles (PubMed:28336330). |
| Cellular Location | Cell membrane; Lipid-anchor. Endoplasmic reticulum membrane; Lipid-anchor. Mitochondrion membrane; Lipid- anchor. Lipid droplet. Note=Translocates from endoplasmic reticulum to lipid droplets in response to oleate |
| Tissue Location | Highly expressed in heart and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PLA2G4C is a protein which is a member of thephospholipase A2 enzyme family which hydrolyzesglycerophospholipids to produce free fatty acids andlysophospholipids, both of which serve as precursors in theproduction of signaling molecules. The encoded protein has beenshown to be a calcium-independent and membrane bound enzyme.
References
Smith, J.S., et al. Genomics 64(1):44-50(2000)Pickard, R.T., et al. J. Biol. Chem. 274(13):8823-8831(1999)Underwood, K.W., et al. J. Biol. Chem. 273(34):21926-21932(1998)Wu, T., et al. J. Biol. Chem. 272(27):17145-17153(1997)
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