|Other Names||Ras-related GTP-binding protein A, Rag A, RagA, Adenovirus E3 147 kDa-interacting protein 1, FIP-1, RRAGA (HGNC:16963)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.|
|Cellular Location||Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state (PubMed:8995684, PubMed:9394008). Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane (PubMed:8995684).|
|Tissue Location||Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain|
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Involved in the RCC1/Ran-GTPase pathway. RRAGA may play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. biquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
Humphray, S.J., et al. Nature 429(6990):369-374(2004)Sekiguchi, T., et al. J. Biol. Chem. 279(9):8343-8350(2004)Sekiguchi, T., et al. J. Biol. Chem. 276(10):7246-7257(2001)Hirose, E., et al. J. Cell. Sci. 111 (PT 1), 11-21 (1998) :Li, Y., et al. J. Virol. 71(2):1576-1582(1997)Schurmann, A., et al. J. Biol. Chem. 270(48):28982-28988(1995)
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