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WDFY2 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96P53 |
|---|---|
| Other Accession | NP_443182.1 |
| Clone Names | 91119291 |
| Gene ID | 115825 |
|---|---|
| Other Names | WD repeat and FYVE domain-containing protein 2, WD40- and FYVE domain-containing protein 2, Zinc finger FYVE domain-containing protein 22, WDFY2, WDF2, ZFYVE22 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | WDFY2 |
|---|---|
| Synonyms | WDF2, ZFYVE22 |
| Function | Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti- adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553). |
| Cellular Location | Endosome. Early endosome. Cytoplasm {ECO:0000250|UniProtKB:Q8BUB4}. Note=Localizes to intracellular vesicles (PubMed:16792529). Colocalizes with VAMP2 and PRKCZ in intracellular vesicles (PubMed:17313651). Colocalizes with AKT2 in early endosomes (By similarity). {ECO:0000250|UniProtKB:Q8BUB4, ECO:0000269|PubMed:16792529, ECO:0000269|PubMed:17313651} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
WDFY2 is a protein that contains two WD domainsand an FYVE zinc finger region. The function of this gene isunknown. An alternatively spliced transcript variant of this genemay exist.
References
Fritzius, T., et al. FEBS J. 274(6):1552-1566(2007)Fritzius, T., et al. Biochem. J. 399(1):9-20(2006)Hayakawa, A., et al. Proc. Natl. Acad. Sci. U.S.A. 103(32):11928-11933(2006)
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