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WDFY2 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96P53
Other Accession NP_443182.1
Clone Names 91119291
Peptide ID 91119291
Additional Information
Gene ID 115825
Other Names WD repeat and FYVE domain-containing protein 2, WD40- and FYVE domain-containing protein 2, Zinc finger FYVE domain-containing protein 22, WDFY2, WDF2, ZFYVE22
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name WDFY2
Synonyms WDF2, ZFYVE22
Function Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553).
Cellular Location Endosome. Early endosome. Cytoplasm {ECO:0000250|UniProtKB:Q8BUB4}. Note=Localizes to intracellular vesicles (PubMed:16792529). Colocalizes with VAMP2 and PRKCZ in intracellular vesicles (PubMed:17313651). Colocalizes with AKT2 in early endosomes (By similarity). {ECO:0000250|UniProtKB:Q8BUB4, ECO:0000269|PubMed:16792529, ECO:0000269|PubMed:17313651}
Research Areas
Citations (0)

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Background

WDFY2 is a protein that contains two WD domainsand an FYVE zinc finger region. The function of this gene isunknown. An alternatively spliced transcript variant of this genemay exist.

References

Fritzius, T., et al. FEBS J. 274(6):1552-1566(2007)Fritzius, T., et al. Biochem. J. 399(1):9-20(2006)Hayakawa, A., et al. Proc. Natl. Acad. Sci. U.S.A. 103(32):11928-11933(2006)

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$ 80.00
Cat# BP5783c
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