Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
SLC22A14 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y267 |
|---|---|
| Other Accession | NP_004794.2 |
| Clone Names | 91216244 |
| Gene ID | 9389 |
|---|---|
| Other Names | Solute carrier family 22 member 14, Organic cation transporter-like 4, ORCTL-4, SLC22A14, OCTL2, ORCTL4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC22A14 {ECO:0000303|PubMed:33882315, ECO:0000312|HGNC:HGNC:8495} |
|---|---|
| Function | Riboflavin transporter localized at the inner mitochondrial membrane of the spermatozoa midpiece, which is required for male fertility (By similarity). SLC22A14-mediated riboflavin transport is essential for spermatozoa energy generation and motility: riboflavin is the precursor of FMN and FAD, which are coenzymes of many enzymes in the TCA cycle (the citric acid cycle) in mitochondria (By similarity). Required for sperm motility and normal sperm flagellar structure (By similarity). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q497L9}; Multi-pass membrane protein. Note=Localizes to the principle piece of the sperm tail {ECO:0000250|UniProtKB:Q497L9} |
| Tissue Location | Ubiquitous.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
SLC22A14 is a member of the organic-cationtransporter family. It is located in a gene cluster with anothermember of the family, organic cation transporter like 3. Theencoded protein is a transmembrane protein which is thought totransport small molecules and since this protein is conserved amongseveral species, it is suggested to have a fundamental role inmammalian systems.
References
Daigo, Y., et al. Cancer Res. 59(8):1966-1972(1999)Daigo, Y., et al. DNA Res. 6(1):37-44(1999)Nishiwaki, T., et al. Cytogenet. Cell Genet. 83 (3-4), 251-255 (1998) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
