|Other Names||Rho guanine nucleotide exchange factor 3, Exchange factor found in platelets and leukemic and neuronal tissues, XPLN, ARHGEF3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.|
|Tissue Location||Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney.|
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Rho-like GTPases are involved in a variety of cellularprocesses, and they are activated by binding GTP and inactivated byconversion of GTP to GDP by their intrinsic GTPase activity.Guanine nucleotide exchange factors (GEFs) accelerate the GTPaseactivity of Rho GTPases by catalyzing their release of bound GDP.This gene encodes a guanine nucleotide exchange factor, whichspecifically activates two members of the Rho GTPase family: RHOAand RHOB, both of which have a role in bone cell biology. It hasbeen identified that genetic variation in this gene plays a role inthe determination of bone mineral density (BMD), indicating theimplication of this gene in postmenopausal osteoporosis.Alternatively spliced transcript variants encoding differentisoforms have been found for this gene.
Arthur, W.T., et al. J. Biol. Chem. 277(45):42964-42972(2002)Harrington, A.W., et al. J. Neurosci. 22(1):156-166(2002)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)Thiesen, S., et al. Biochem. Biophys. Res. Commun. 273(1):364-369(2000)
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