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ARHGEF3 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9NR81
Other Accession NP_062455.1
Clone Names 90723144
Peptide ID 90723144
Additional Information
Gene ID 50650
Other Names Rho guanine nucleotide exchange factor 3, Exchange factor found in platelets and leukemic and neuronal tissues, XPLN, ARHGEF3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
Cellular Location Cytoplasm.
Tissue Location Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney.
Research Areas
Citations (0)

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Rho-like GTPases are involved in a variety of cellularprocesses, and they are activated by binding GTP and inactivated byconversion of GTP to GDP by their intrinsic GTPase activity.Guanine nucleotide exchange factors (GEFs) accelerate the GTPaseactivity of Rho GTPases by catalyzing their release of bound GDP.This gene encodes a guanine nucleotide exchange factor, whichspecifically activates two members of the Rho GTPase family: RHOAand RHOB, both of which have a role in bone cell biology. It hasbeen identified that genetic variation in this gene plays a role inthe determination of bone mineral density (BMD), indicating theimplication of this gene in postmenopausal osteoporosis.Alternatively spliced transcript variants encoding differentisoforms have been found for this gene.


Arthur, W.T., et al. J. Biol. Chem. 277(45):42964-42972(2002)Harrington, A.W., et al. J. Neurosci. 22(1):156-166(2002)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)Thiesen, S., et al. Biochem. Biophys. Res. Commun. 273(1):364-369(2000)

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$ 80.00
Cat# BP5820c
Availability: In Stock
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