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HAND2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P61296
Other Accession NP_068808
Clone Names 2082305
Peptide ID 2082305
Additional Information
Gene ID 9464
Other Names Heart- and neural crest derivatives-expressed protein 2, Class A basic helix-loop-helix protein 26, bHLHa26, Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, dHAND, HAND2, BHLHA26, DHAND
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6117a was selected from the C-term region of human HAND2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HAND2
Synonyms BHLHA26, DHAND
Function Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}
Tissue Location Heart.
Research Areas
Citations (0)

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HAND2 belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.


McFadden, D.G., et al., Development 127(24):5331-5341 (2000).Firulli, A.B., et al., Nat. Genet. 18(3):266-270 (1998).Russell, M.W., et al., Biochim. Biophys. Acta 1443(3):393-399 (1998).Srivastava, D., Trends Cardiovasc Med 9 (1-2), 11-18 (1999).Srivastava, D., et al., Cold Spring Harb. Symp. Quant. Biol. 67, 121-125 (2002).

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$ 80.00
Cat# BP6117a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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