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ABCB5 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q2M3G0
Clone Names 80305103
Peptide ID 80305103
Additional Information
Gene ID 340273
Other Names ATP-binding cassette sub-family B member 5, ABCB5 P-gp, P-glycoprotein ABCB5, ABCB5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6122a was selected from the N-term region of human ABCB5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCB5
Function Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.
Cellular Location Cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:12960149}
Tissue Location Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium.
Research Areas
Citations (0)

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ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules.


Frank,N.Y., Cancer Res. 65 (10), 4320-4333 (2005)Chen,K.G., Pigment Cell Res. 18 (2), 102-112 (2005)Frank,N.Y., J. Biol. Chem. 278 (47), 47156-47165 (2003)

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$ 80.00
Cat# BP6122a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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