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ABCB8 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NUT2 |
|---|---|
| Clone Names | 80325101 |
| Gene ID | 11194 |
|---|---|
| Other Names | ATP-binding cassette sub-family B member 8, mitochondrial, Mitochondrial ATP-binding cassette 1, M-ABC1, ABCB8, MABC1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6129a was selected from the N-term region of human ABCB8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ABCB8 {ECO:0000303|PubMed:25944712, ECO:0000312|HGNC:HGNC:49} |
|---|---|
| Function | ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane (PubMed:31435016). Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (PubMed:31435016). Plays a role in mitochondrial iron transport (PubMed:30623799). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441} |
| Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ABCB8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC proteins are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. The protein may also play a role in the transport of phospholipids into mitochondrial membranes.
References
Saito S., Iida A., Sekine A.J. Hum. Genet. 47:38-50(2002)
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