CDX4 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O14627 |
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Clone Names | 2080401 |
Gene ID | 1046 |
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Other Names | Homeobox protein CDX-4, Caudal-type homeobox protein 4, CDX4 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6132a was selected from the N-term region of human CDX4 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CDX4 |
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Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CDX4 is a member of the 'caudal-related' family of homeo box genes. It is located in the mouse 100 kb distal to Xist, and the 2 genes are transcribed convergently. It has been demonstrated that CDX4 is located proximal to XIST in the human.1 In contrast to Xist, Cdx4 appears to be normally X-inactivated in mice. CDX4 is identified as the locus mutated in 'kugelig' (kgg), a zebrafish mutant with an early defect in hematopoiesis that is associated with abnormal anteroposterior patterning and aberrant hox gene expression.2 A series of evidence from the zebrafish mutant model suggests that cdx4 regulates hox genes and is necessary for the specification of hematopoietic cell fate during vertebrate embryogenesis.
References
Horn, J.M., et al., Hum. Mol. Genet. 4(6):1041-1047 (1995).
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