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GREMLIN Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O70326
Clone Names 2090704
Peptide ID 2090704
Additional Information
Gene ID 23892
Other Names Gremlin-1, Cysteine knot superfamily 1, BMP antagonist 1, Down-regulated in Mos-transformed cells protein, Grem1, Cktsf1b1, Drm
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6133a was selected from the C-term region of human GREMLIN . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Grem1
Synonyms Cktsf1b1, Drm
Function Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as BMP a antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis.
Cellular Location Secreted.
Tissue Location Highly expressed in spleen and to a lesser extent in lung, skeletal muscle and kidney. Expressed only in non- transformed cells or primary fibroblasts in culture but not in established transformed or tumor derived cell lines. Broadly expressed in limb bud mesenchyme but restricted to the distal limb bud mesenchyme and concentrated posteriorly. Expressed in ovary especially in granulosa cells of follicles of type 4
Research Areas
Citations (0)

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Using a Xenopus expression-cloning screen, Gremlin was isolated as an antagonist of bone morphogenetic protein (BMP) signaling that is expressed in the neural crest. Gremlin belongs to a novel gene family that includes the head-inducing factor Cerberus and the tumor suppressor DAN. All these family members are secreted proteins that act as BMP antagonists in embryonic explants. The proposed function of Gremlin, Cerberus, and DAN is a BMP signaling blocking activity by binding BMPs, preventing them from interacting with their receptors. Gremlin, Cerberus, and DAN may control diverse processes in growth and development by selectively antagonizing the activities of different subsets of the transforming growth factor (TGF)-beta ligands. By homology searches, Hsu et al. (1998) cloned the human homolog of Xenopus Gremlin. The human gremlin cDNA encodes a predicted 184-amino acid protein.


Hsu DR, et al. Molec. Cell 1998. 1: 673. Khokha MK, et al. Nature Genet. 2003. 34: 303. Topol LZ, et al. Cytogenet. Cell Genet. 2000. 89: 79. Zuniga A, et al. Nature 1999. 401: 598.

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$ 80.00
Cat# BP6133a
Availability: In Stock
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