|Other Names||Prolyl 3-hydroxylase 1, Growth suppressor 1, Leucine- and proline-enriched proteoglycan 1, Leprecan-1, LEPRE1, GROS1, P3H1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6145a was selected from the C-term region of human GROS1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts.|
|Cellular Location||Isoform 1: Endoplasmic reticulum.|
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Provided below are standard protocols that you may find useful for product applications.
GROS1 is a tumor suppressor protein encoded by a gene on human chromosome 1p31, a region mutated in many malignancies. Gros1 identity to leprecan, a basement membrane-associated proteoglycan, has been reported. The precise cellular function of GROS1 has not been determined.
Kaul, S.C., et al., Oncogene 19(32):3576-3583 (2000).
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