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GROS1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q32P28 |
|---|---|
| Other Accession | NP_071751 |
| Gene ID | 64175 |
|---|---|
| Other Names | Prolyl 3-hydroxylase 1, Growth suppressor 1, Leucine- and proline-enriched proteoglycan 1, Leprecan-1, LEPRE1, GROS1, P3H1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6145a was selected from the C-term region of human GROS1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | P3H1 (HGNC:19316) |
|---|---|
| Function | Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. |
| Cellular Location | [Isoform 1]: Endoplasmic reticulum |
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Provided below are standard protocols that you may find useful for product applications.
Background
GROS1 is a tumor suppressor protein encoded by a gene on human chromosome 1p31, a region mutated in many malignancies. Gros1 identity to leprecan, a basement membrane-associated proteoglycan, has been reported. The precise cellular function of GROS1 has not been determined.
References
Kaul, S.C., et al., Oncogene 19(32):3576-3583 (2000).
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