|Other Names||AF4/FMR2 family member 3, Lymphoid nuclear protein related to AF4, Protein LAF-4, AFF3, LAF4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6149a was selected from the C-term region of human LAF4 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double- stranded DNA.|
|Tissue Location||Preferentially expressed in lymphoid tissues, highest levels being found in the thymus|
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Provided below are standard protocols that you may find useful for product applications.
Lymphoid nuclear protein related to AF4 (LAF4) is related to MLLT2 which is also referred to as AF4. LAF4 is a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of LAF4 has defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis.
Hiwatari, M., et al., Oncogene 22(18):2851-2855 (2003).von Bergh, A.R., et al., Genes Chromosomes Cancer 35(1):92-96 (2002).Liao, X., et al., Mamm. Genome 7(6):467-468 (1996).Ma, C., et al., Blood 87(2):734-745 (1996).
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