|Other Names||Low-density lipoprotein receptor-related protein 2, LRP-2, Glycoprotein 330, gp330, Megalin, LRP2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6154a was selected from the C-term region of human LRP2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release.|
|Cellular Location||Membrane; Single-pass type I membrane protein. Membrane, coated pit|
|Tissue Location||Absorptive epithelia, including renal proximal tubules|
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Low density lipoprotein (LDL) receptor-related protein (LRP), a member of the LDL receptor family, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, protease clearance, and cell migration (1). Structurally, members of the LDLR family share homology within their extracellular domains, which are highlighted by the presence of clusters of ligand-binding repeats. LRP is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis. LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes (2). All LRPs are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family (3).
Christensen, E.I., et al., Nat. Rev. Mol. Cell Biol. 3(4):256-266 (2002).Hjalm, G., et al., Eur. J. Biochem. 239(1):132-137 (1996).Farquhar, M.G., et al., J. Am. Soc. Nephrol. 6(1):35-47 (1995).Kounnas, M.Z., et al., J. Biol. Chem. 270(22):13070-13075 (1995).Korenberg, J.R., et al., Genomics 22(1):88-93 (1994).
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