|Other Names||Melanoma-associated antigen B3, MAGE-B3 antigen, MAGEB3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6173a was selected from the N-term region of human MAGEB3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed in testis.|
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Provided below are standard protocols that you may find useful for product applications.
MAGEB3 is a MAGE-B subfamily member of the MAGE gene family. MAGE family member proteins direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. There are two known clusters of MAGE genes on chromosome X. The members of the MAGE-A subfamily are located in the Xq28 region, while the members of the MAGE-B subfamily are clustered in the Xp21 region.
Lurquin, C., et al., Genomics 46(3):397-408 (1997).
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