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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   AF4 (MLLT2) Antibody (Center) Blocking peptide   

AF4 (MLLT2) Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P51825
Clone Names 4091610
Additional Information
Gene ID 4299
Other Names AF4/FMR2 family member 1, ALL1-fused gene from chromosome 4 protein, Protein AF-4, Protein FEL, Proto-oncogene AF4, AFF1, AF4, FEL, MLLT2, PBM1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6189c was selected from the Center region of human MLLT2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AFF1
Synonyms AF4, FEL, MLLT2, PBM1
Cellular Location Nucleus.
Research Areas
Citations (0)

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MLLT2 is involved in acute leukemias through a chromosomal translocation t(4;11)(q21;q23) that involves mllt2 and mll/hrx. AF-4 (MLLT2), AF-9, and ENL proteins contain nuclear targeting sequences as well as serine-rich and proline-rich regions. Stretches abundant in basic amino acids are also present in the three proteins. These results suggest that the different proteins fused to ALL-1 polypeptide(s) provide similar functional domains. AF4 is a serine- and proline-rich putative transcription factor with a glutamine-rich carboxyl terminus. The composition of the complete MLL-AF4 fusion product argues that it may act through either a gain-of-function or a dominant negative mechanism in leukemogenesis.


Bursen, A., et al., Oncogene 23(37):6237-6249 (2004).Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135 (2004).Caslini, C., et al., Leukemia 18(6):1064-1071 (2004).Bertrand, F.E., et al., Leukemia 17(12):2454-2459 (2003).Reichel, M., et al., Leukemia 15(2):286-288 (2001).

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$ 80.00
Cat# BP6189c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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