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MVP Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q14764
Other Accession NP_005106
Clone Names 2090705
Peptide ID 2090705
Additional Information
Gene ID 9961
Other Names Major vault protein, MVP, Lung resistance-related protein, MVP, LRP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6216a was selected from the C-term region of human MVP . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MVP
Synonyms LRP
Function Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Cellular Location Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment
Tissue Location Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells
Research Areas
Citations (0)

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MVP, the major vault protein, is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance.


Aronica, E., et al., Epilepsia 44(9):1166-1175 (2003).Klunder, J.W., et al., Hum. Pathol. 34(2):150-155 (2003).Burger, H., et al., Clin. Cancer Res. 9(2):827-836 (2003).Yu, Z., et al., J. Biol. Chem. 277(43):40247-40252 (2002).van den Heuvel-Eibrink, M.M., et al., Leukemia 16(5):833-839 (2002).

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$ 80.00
Cat# BP6216a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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