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OAS3 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9Y6K5
Clone Names 2081606
Peptide ID 2081606
Additional Information
Gene ID 4940
Other Names 2'-5'-oligoadenylate synthase 3, (2-5')oligo(A) synthase 3, 2-5A synthase 3, p100 OAS, p100OAS, OAS3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6228a was selected from the C-term region of human OAS3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name OAS3
Function Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
Cellular Location Cytoplasm. Nucleus.
Tissue Location Present at high level in placenta trophoblast.
Research Areas
Citations (0)

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OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.


Ito, M., et al., Cancer Res. 61(5):2038-2046 (2001).Rebouillat, D., et al., Genomics 70(2):232-240 (2000).Rebouillat, D., et al., J. Biol. Chem. 274(3):1557-1565 (1999).

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$ 80.00
Cat# BP6228a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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