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OASL Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q15646
Clone Names 2081607
Peptide ID 2081607
Additional Information
Gene ID 8638
Other Names 2'-5'-oligoadenylate synthase-like protein, 2'-5'-OAS-related protein, 2'-5'-OAS-RP, 59 kDa 2'-5'-oligoadenylate synthase-like protein, Thyroid receptor-interacting protein 14, TR-interacting protein 14, TRIP-14, p59 OASL, p59OASL, OASL, TRIP14
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6230a was selected from the C-term region of human OASL . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms TRIP14
Function Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.
Cellular Location Isoform p56: Nucleus, nucleolus. Cytoplasm.
Tissue Location Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis
Research Areas
Citations (0)

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2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted 514-amino acid human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.


Hovnanian, A., et al., Genomics 56(3):362-363 (1999).Rebouillat, D., et al., Eur. J. Biochem. 257(2):319-330 (1998).Hartmann, R., et al., Nucleic Acids Res. 26(18):4121-4128 (1998).Lee, J.W., et al., Mol. Endocrinol. 9(2):243-254 (1995).Mackay, V., et al., J. Biol. Chem. 251(12):3716-3719 (1976).

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$ 80.00
Cat# BP6230a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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