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RAI14 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9P0K7
Other Accession NP_056392
Additional Information
Gene ID 26064
Other Names Ankycorbin, Ankyrin repeat and coiled-coil structure-containing protein, Novel retinal pigment epithelial cell protein, Retinoic acid-induced protein 14, RAI14, KIAA1334, NORPEG
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6233a was selected from the C-term region of human RAI14 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAI14
Synonyms KIAA1334, NORPEG
Function Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier.
Cellular Location Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9P0K7}. Cytoplasm, cytoskeleton. Cell junction {ECO:0000250|UniProtKB:Q5U312}. Nucleus. Note=Associated with the cortical actin cytoskeleton structures in terminal web and cell-cell adhesion sites and stress fibers (By similarity). Highly expressed at the ectoplasmic specialization, an actin-rich cell junction specific to the testis (By similarity). Predominantly nuclear in nonconfluent cells (PubMed:16729964) {ECO:0000250|UniProtKB:Q5U312, ECO:0000250|UniProtKB:Q9P0K7, ECO:0000269|PubMed:16729964}
Tissue Location Highly expressed in placenta, muscle, kidney and testis. Moderately expressed in heart, brain, lung, liver and intestine. Isoform 2 is widely expressed and expressed in fetal and adult testes, and spermatozoa.
Research Areas
Citations (0)

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Retinoic acid plays a critical role in development, cellular growth, and differentiation and induces the expression of a variety of genes. RAI14 is expressed in retinal pigment epithelial cells, induced by all-trans-retinoic acid. Highest expression of RAI14 occurs in the placenta and testis. The predicted human RAI14 protein consists of 980 amino acids, and features 6 potential N-glycosylation sites, six ankyrin repeats and several coiled-coil helical domains. RAI14, which localizes to the cytoplasm, is also highly expressed in several human cancer cell lines. The precise cellular function of RAI14 remains to be determined.


Kutty, R.K., et al., J. Biol. Chem. 276(4):2831-2840 (2001).

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$ 80.00
Cat# BP6233a
Availability: In Stock
Bulk Size
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