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RAI3 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8NFJ5
Other Accession NP_003970
Clone Names 2081902
Peptide ID 2081902
Additional Information
Gene ID 9052
Other Names Retinoic acid-induced protein 3, G-protein coupled receptor family C group 5 member A, Orphan G-protein-coupling receptor PEIG-1, Retinoic acid-induced gene 1 protein, RAIG-1, GPRC5A, GPCR5A, RAI3, RAIG1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6239a was selected from the C-term region of human RAI3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms GPCR5A, RAI3, RAIG1
Function Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218).
Cellular Location Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in perinuclear vesicles, probably Golgi-associated vesicles.
Tissue Location Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers (PubMed:9857033, PubMed:18000218). Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart
Research Areas
Citations (0)

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Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function for the protein from this retinoic acid-induced gene has not yet been determined; however, it may play a role in embryonic development and epithelial cell differentiation. Rai3 is a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. It may also be involved in interaction between retinoid acid and G protein signalling pathways.


Robbins, M.J., et al., Genomics 67(1):8-18 (2000).Cheng, Y., et al., J. Biol. Chem. 273(52):35008-35015 (1998).Cafferata, E.G., et al., Cell. Mol. Biol. (Noisy-le-grand) 42(5):797-804 (1996).

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$ 80.00
Cat# BP6239a
Availability: In Stock
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