|Other Names||Retinoic acid-induced protein 3, G-protein coupled receptor family C group 5 member A, Orphan G-protein-coupling receptor PEIG-1, Retinoic acid-induced gene 1 protein, RAIG-1, GPRC5A, GPCR5A, RAI3, RAIG1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6239a was selected from the C-term region of human RAI3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPCR5A, RAI3, RAIG1|
|Function||Unknown. This G-protein coupled receptor could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. The comparable expression level in fetal lung and kidney with adult tissues suggests a possible role in embryonic development and maturation of these organs. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein Note=Localized in the plasma membrane and perinuclear vesicles|
|Tissue Location||Expressed at high level in fetal and adult lung tissues. Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart|
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Provided below are standard protocols that you may find useful for product applications.
Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function for the protein from this retinoic acid-induced gene has not yet been determined; however, it may play a role in embryonic development and epithelial cell differentiation. Rai3 is a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. It may also be involved in interaction between retinoid acid and G protein signalling pathways.
Robbins, M.J., et al., Genomics 67(1):8-18 (2000).Cheng, Y., et al., J. Biol. Chem. 273(52):35008-35015 (1998).Cafferata, E.G., et al., Cell. Mol. Biol. (Noisy-le-grand) 42(5):797-804 (1996).
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