|Other Names||Sclerostin, SOST|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6261c was selected from the Center region of human SOST. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of the sclerostin gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Semenov,M.V., J. Biol. Chem. 281 (50), 38276-38284 (2006)Ellies,D.L., J. Bone Miner. Res. 21 (11), 1738-1749 (2006)Balemans,W., J Musculoskelet Neuronal Interact 6 (4), 355-356 (2006)Gardner,J.C., J. Clin. Endocrinol. Metab. 90 (12), 6392-6395 (2005)
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