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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Presenilin 2 (PSEN2) Antibody (C-term) Blocking peptide   

Presenilin 2 (PSEN2) Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P49810
Other Accession PSN2_HUMAN
Clone Names 3120822
Peptide ID 3120822
Additional Information
Gene ID 5664
Other Names Presenilin-2, PS-2, 3423-, AD3LP, AD5, E5-1, STM-2, Presenilin-2 NTF subunit, Presenilin-2 CTF subunit, PSEN2, AD4, PS2, PSNL2, STM2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6305a was selected from the C-term region of human PSN2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PSEN2
Synonyms AD4, PS2, PSNL2, STM2
Function Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein
Tissue Location Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney
Research Areas
Citations (0)

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Background

PSEN2 is the probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). The gamma-secretase complex is composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. PSEN2 requires the other members of the gamma-secretase complex to have a protease activity. This protein may play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane, and may also function in the cytoplasmic partitioning of proteins. PSEN2 has been shown to interact with HERPUD1, FLNA and FLNB. The protein appears to localize to the Golgi and endoplasmic reticulum. Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney. Defects in PSEN2 are the cause of an inherited form of Alzheimer disease (AD), an autosomal dominant neurodegenerative disorder characterized by progressive dementia, parkinsonism, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. Three causative genes have been identified that when mutated lead to presenile Alzheimer's disease: APP (amyloid precursor protein gene), PSEN1 and PSEN2. These three genes account for half of the families with autosomal dominant presenile AD, which represent approximately 10% of the whole AD population.

References

Sai, X., et al., J. Biol. Chem. 277(15):12915-12920 (2002).Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Finckh, U., et al., Am. J. Hum. Genet. 66(1):110-117 (2000).Kimberly, W.T., et al., J. Biol. Chem. 275(5):3173-3178 (2000).Steiner, H., et al., J. Biol. Chem. 274(40):28669-28673 (1999).

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$ 80.00
Cat# BP6305a
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