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SPPL3 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8TCT6
Clone Names 2092806
Additional Information
Gene ID 121665
Other Names Signal peptide peptidase-like 3, SPP-like 3, 3423-, Intramembrane protease 2, IMP-2, Presenilin homologous protein 1, PSH1, Presenilin-like protein 4, SPPL3, IMP2, PSL4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6313b was selected from the C-term region of human SPPL3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPPL3
Synonyms IMP2, PSL4
Function Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.
Cellular Location Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein Note=Restricted to the early secretory compartment
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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Signal peptide peptidase (SPP) is an aspartyl protease that mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER). Like presenilins, SPP contains a critical GXGD motif in its C-terminal catalytic center. SPPL3 is one of several presenilin homologues/SPP-like proteins (PSHs/SPPL) that have been identified.


Grigorenko, A.P., et al., Biochemistry Mosc. 67(7):826-835 (2002).Weihofen, A., et al., Science 296(5576):2215-2218 (2002).

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$ 80.00
Cat# BP6313b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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