|Other Names||Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Regulator of calcineurin 1, RCAN1, ADAPT78, CSP1, DSC1, DSCR1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6315a was selected from the N-term region of human DSCR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ADAPT78, CSP1, DSC1, DSCR1|
|Function||Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.|
|Tissue Location||Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues|
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DSCR1 (calcipressin 1) interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. Thr gene for this protein is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease.
Minami, T., et al., J. Biol. Chem. 279(48):50537-50554 (2004).Yao, Y.G., et al., Biochem. Biophys. Res. Commun. 321(3):648-656 (2004).Michtalik, H.J., et al., Free Radic. Biol. Med. 37(4):454-462 (2004).Hesser, B.A., et al., Blood 104(1):149-158 (2004).Iizuka, M., et al., Biochem. Biophys. Res. Commun. 41(4):334-344 (2004).
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