|Other Accession||P51792, O18894, P51791, O14918|
|Other Names||H(+)/Cl(-) exchange transporter 3, Chloride channel protein 3, ClC-3, Chloride transporter ClC-3, CLCN3|
|Target/Specificity||The synthetic peptide sequence is selected from aa 677~691 of HUMAN CLCN3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.|
|Cellular Location||Isoform 1: Membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein Late endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Note=Isoform 1 is localized mainly in early and late endosomes|
|Tissue Location||Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Salazar, G., et al., J. Biol. Chem. 279(24):25430-25439 (2004).
Gentzsch, M., et al., J. Biol. Chem. 278(8):6440-6449 (2003).
Olsen, M.L., et al., J. Neurosci. 23(13):5572-5582 (2003).
Hermoso, M., et al., J. Biol. Chem. 277(42):40066-40074 (2002).
Huang, P., et al., J. Biol. Chem. 276(23):20093-20100 (2001).
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