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Drosophila Parkin Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q7KTX7
Clone Names 5070552
Additional Information
Gene ID 40336
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6414b was selected from the C-term region of human Drosophila Parkin. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Q7KTX7
Function Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
Research Areas
Citations (0)

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Background

Parkin is thought to play a role in the ubiquitin/proteasome pathway for protein degradation. The amino terminus bears sequence homology to ubiquitin while functionally it acts as a RING-type ubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome. Mutations in the human version of the protein are known to cause autosomal recessive juvenile parkinsonism.

References

Zhong,L. et al. J. Biol. Chem. 280 (10), 9425-9430 (2005) Pesah,Y. et al. Development 131 (9), 2183-2194 (2004) Haywood,A.F. et al. BMC Neurosci 5, 14 (2004) Finney,N. et al. J. Biol. Chem. 278 (18), 16054-16058 (2003) Yang,Y. et al. Neuron 37 (6), 911-924 (2003)

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$ 80.00
Cat# BP6414b
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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