|Other Names||Copper-transporting ATPase 2, Copper pump 2, Wilson disease-associated protein, WND/140 kDa, ATP7B, PWD, WC1, WND|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6504b was selected from the C-term region of human ATP7B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||PWD, WC1, WND|
|Function||Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Multi- pass membrane protein. Late endosome Note=Predominantly found in the trans-Golgi network (TGN) Localized in the trans-Golgi network under low copper conditions, redistributes to cytoplasmic vesicles when cells are exposed to elevated copper levels, and then recycles back to the trans-Golgi network when copper is removed (PubMed:10942420). Not redistributed to the plasma membrane in response to elevated copper levels. Isoform 2: Cytoplasm|
|Tissue Location||Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver The cleaved form WND/140 kDa is found in liver cell lines and other tissues|
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Provided below are standard protocols that you may find useful for product applications.
ATP7B is a member of the P-type cation transport ATPase family and a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile.
Martinez-Balibrea,E., Int. J. Cancer 124 (12), 2905-2910 (2009)
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