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ATP7B Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P35670
Clone Names 80722022
Peptide ID 80722022
Additional Information
Gene ID 540
Other Names Copper-transporting ATPase 2, Copper pump 2, Wilson disease-associated protein, WND/140 kDa, ATP7B, PWD, WC1, WND
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6504b was selected from the C-term region of human ATP7B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATP7B
Synonyms PWD, WC1, WND
Function Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
Cellular Location Golgi apparatus, trans-Golgi network membrane; Multi- pass membrane protein. Late endosome Note=Predominantly found in the trans-Golgi network (TGN) Localized in the trans-Golgi network under low copper conditions, redistributes to cytoplasmic vesicles when cells are exposed to elevated copper levels, and then recycles back to the trans-Golgi network when copper is removed (PubMed:10942420). Not redistributed to the plasma membrane in response to elevated copper levels. Isoform 2: Cytoplasm
Tissue Location Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver The cleaved form WND/140 kDa is found in liver cell lines and other tissues
Research Areas
Citations (0)

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Background

ATP7B is a member of the P-type cation transport ATPase family and a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile.

References

Martinez-Balibrea,E., Int. J. Cancer 124 (12), 2905-2910 (2009)

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$ 80.00
Cat# BP6504b
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