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EMD Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P50402
Clone Names 81006119
Peptide ID 81006119
Additional Information
Gene ID 2010
Other Names Emerin, EMD, EDMD, STA
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6525a was selected from the N-term region of human EMD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name EMD
Synonyms EDMD, STA
Function Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
Cellular Location Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non- farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus
Tissue Location Skeletal muscle, heart, colon, testis, ovary and pancreas
Research Areas
Citations (0)

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Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene.


Asioli,S., Histopathology 54 (5), 571-579 (2009)Tilgner,K., J. Cell. Sci. 122 (PT 3), 401-413 (2009)

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$ 80.00
Cat# BP6525a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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