|Other Names||Actin-related protein 2, Actin-like protein 2, ACTR2, ARP2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6533c was selected from the Center region of human ACTR2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection|
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Provided below are standard protocols that you may find useful for product applications.
ACTR2 is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion.
Gonzalez,V., Cell Host Microbe 5 (3), 259-272 (2009)Weisswange,I., Nature 458 (7234), 87-91 (2009)
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