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ANGPTL7 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O43827 |
|---|---|
| Clone Names | 80411120 |
| Gene ID | 10218 |
|---|---|
| Other Names | Angiopoietin-related protein 7, Angiopoietin-like factor, Angiopoietin-like protein 7, Cornea-derived transcript 6 protein, ANGPTL7, CDT6 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6535a was selected from the N-term region of human ANGPTL7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ANGPTL7 |
|---|---|
| Synonyms | CDT6 |
| Function | Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (PubMed:21199193). Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency (PubMed:25622036). |
| Cellular Location | Secreted. |
| Tissue Location | Highly expressed in the cornea (at protein level) (PubMed:11682471). Expression is restricted to the stromal layer (PubMed:11682471). Also detected at the junction between the corneal stromal layer and the conjuctiva. Not detected in the sclera (PubMed:11682471). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Kuchtey,J., Invest. Ophthalmol. Vis. Sci. 49 (8), 3438-3448 (2008)
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$ 277.78
Cat# BP6535a
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