|Other Names||Protein NOV homolog, NovH, CCN family member 3, Insulin-like growth factor-binding protein 9, IBP-9, IGF-binding protein 9, IGFBP-9, Nephroblastoma-overexpressed gene protein homolog, NOV, CCN3, IGFBP9, NOVH|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6537a was selected from the N-term region of human NOV. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CCN3, IGFBP9, NOVH|
|Function||Immediate-early protein likely to play a role in cell growth regulation.|
|Tissue Location||Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type.|
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Provided below are standard protocols that you may find useful for product applications.
NOV is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development.
Ghayad,S.E., J. Mol. Endocrinol. 42 (2), 87-103 (2009)Perbal,B., Clin. Cancer Res. 14 (3), 701-709 (2008)Vallacchi,V., Cancer Res. 68 (3), 715-723 (2008)
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