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WTX Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q5JTC6
Clone Names 80821059
Peptide ID 80821059
Additional Information
Gene ID 139285
Other Names APC membrane recruitment protein 1, Amer1, Protein FAM123B, Wilms tumor gene on the X chromosome protein, AMER1, FAM123B, WTX
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6553c was selected from the Center region of human WTX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AMER1
Synonyms FAM123B, WTX
Function Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta- catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Translocates to the cell membrane following binding to PtdIns(4,5)P2
Tissue Location Detected in fetal and adult kidney, brain and spleen.
Research Areas
Citations (0)

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WTX is involved in kidney development.


Rivera,M.N., Proc. Natl. Acad. Sci. U.S.A. 106 (20), 8338-8343 (2009)Fukuzawa,R., Oncogene 28 (8), 1063-1075 (2009)

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$ 80.00
Cat# BP6553c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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