SPB3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P29508 |
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Clone Names | 80808057 |
Gene ID | 6317 |
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Other Names | Serpin B3, Protein T4-A, Squamous cell carcinoma antigen 1, SCCA-1, SERPINB3, SCCA, SCCA1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6579a was selected from the N-term region of human SPB3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SERPINB3 |
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Synonyms | SCCA, SCCA1 |
Function | May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). |
Cellular Location | Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level |
Tissue Location | Squamous cells. Expressed in some hepatocellular carcinoma (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
SPB3 may act as a protease inhibitor to modulate the host immune response against tumor cells.
References
Turato,C., Dig Liver Dis 41 (3), 212-216 (2009)Ahmed,S.T., Biochem. Biophys. Res. Commun. 378 (4), 821-825 (2009)
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