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DCTN2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q13561
Clone Names 81006074
Peptide ID 81006074
Additional Information
Gene ID 10540
Other Names Dynactin subunit 2, 50 kDa dynein-associated polypeptide, Dynactin complex 50 kDa subunit, DCTN-50, p50 dynamitin, DCTN2, DCTN50
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6591a was selected from the N-term region of human DCTN2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCTN2
Synonyms DCTN50
Function Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Membrane; Peripheral membrane protein
Research Areas
Citations (0)

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DCTN2 is a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.


Maier,K.C., Traffic 9 (4), 481-491 (2008)

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$ 80.00
Cat# BP6591a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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