|Other Names||Protein Wnt-10b, Protein Wnt-12, WNT10B, WNT12|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6595b was selected from the Center region of human WNT10B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain|
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Provided below are standard protocols that you may find useful for product applications.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT10B is a member of the WNT family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level.
Zmuda,J.M., J. Bone Miner. Res. 24 (3), 437-447 (2009)Pederson,L., Proc. Natl. Acad. Sci. U.S.A. 105 (52), 20764-20769 (2008)
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