|Other Names||Protein Wnt-10b, Protein Wnt-12, WNT10B, WNT12|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6595b was selected from the Center region of human WNT10B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain|
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Provided below are standard protocols that you may find useful for product applications.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT10B is a member of the WNT family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level.
Zmuda,J.M., J. Bone Miner. Res. 24 (3), 437-447 (2009)Pederson,L., Proc. Natl. Acad. Sci. U.S.A. 105 (52), 20764-20769 (2008)
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