|Other Names||Translocator protein, Mitochondrial benzodiazepine receptor, PKBS, Peripheral-type benzodiazepine receptor, PBR, TSPO, BZRP, MBR|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6606b was selected from the C-term region of human BZRP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678).|
|Cellular Location||Mitochondrion membrane; Multi-pass membrane protein|
|Tissue Location||Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.|
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Provided below are standard protocols that you may find useful for product applications.
Present mainly in the mitochondrial compartment of peripheral tissues, the protein BZRP interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis.
Cosenza-Nashat,M., Neuropathol. Appl. Neurobiol. 35 (3), 306-328 (2009)Karry,R., Pharmacogenet. Genomics 18 (11), 977-988 (2008)
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