BZW2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y6E2 |
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Clone Names | 80924088 |
Gene ID | 28969 |
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Other Names | Basic leucine zipper and W2 domain-containing protein 2, BZW2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6607a was selected from the N-term region of human BZW2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | BZW2 |
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Synonyms | 5MP1 {ECO:0000303|PubMed:21745818} |
Function | Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:21745818, PubMed:28981728, PubMed:34260931, PubMed:29470543). Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C- binding dependent manner (PubMed:21745818, PubMed:28981728, PubMed:34260931). |
Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
BZW2 may be involved in neuronal differentiation.
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