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CCNL1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UK58 |
|---|---|
| Clone Names | 80924105 |
| Gene ID | 57018 |
|---|---|
| Other Names | Cyclin-L1, Cyclin-L, CCNL1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6610b was selected from the C-term region of human CCNL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CCNL1 |
|---|---|
| Function | Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto- oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036). |
| Cellular Location | Nucleus speckle. Nucleus, nucleoplasm. Note=Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. |
| Tissue Location | Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC) |
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Provided below are standard protocols that you may find useful for product applications.
Background
CCNL1 is a transcriptional regulator which participates in regulating the pre-mRNA splicing process. The protein seems to be involved in the regulation of RNA polymerase II (pol II). It functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. It may be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.
References
Loyer,P., J. Biol. Chem. 283 (12), 7721-7732 (2008)Herrmann,A., FASEB J. 21 (12), 3142-3152 (2007)
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