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RNGTT Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O60942 |
|---|---|
| Clone Names | 80924175 |
| Gene ID | 8732 |
|---|---|
| Other Names | mRNA-capping enzyme, HCAP1, HCE, Polynucleotide 5'-triphosphatase, mRNA 5'-triphosphatase, TPase, mRNA guanylyltransferase, GTP--RNA guanylyltransferase, GTase, RNGTT, CAP1A |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6617b was selected from the C-term region of human RNGTT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RNGTT |
|---|---|
| Synonyms | CAP1A |
| Function | Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate. |
| Cellular Location | Nucleus. |
| Tissue Location | Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
RNGTT is a bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. The protein catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.
References
Zhou,M., Proc. Natl. Acad. Sci. U.S.A. 100 (22), 12666-12671 (2003)Chiu,Y.L., J. Biol. Chem. 276 (16), 12959-12966 (2001)
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